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BRCA1 and BRCA2 |
There are certain patients who are genetically
predisposed to getting breast cancer.
While the gene is prevalent in people of the Ashkenazi Jewish background,
the genetic mutation can occur in an individual of any cultural background.
Often individuals with a strong family history are tested for the BRCA 1 and
BRCA 2 gene. If positive, there
is an 80%+ chance of developing breast cancer and about a 40% chance of
developing ovarian cancer. The
recommendation for a woman who carries this gene is to have
prophylactic mastectomies (bilateral) and reconstruction.
If the woman is past child bearing, it is recommended to also
remove the ovaries. A woman who
presents with breast cancer and who is BRCA positive would have a curative
mastectomy on one side and a
prophylactic mastectomy on the other side.
Tissue reconstruction with either DIEP flaps or
bilateral GAP flaps will leave the patient with
soft, natural breasts.
5-10% of patients with breast cancer positive for this genetic mutation.
Testing is simple and only involves a blood test. No removal of breast
tissue is necessary to make the diagnosis of this genetic mutation. |
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